Vibratess
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THz spectroscopy and biosensors

VIBRATESS, LLC

Company Overview

Vibratess, LLC (Vibrational Terahertz Spectroscopic Sensors) was  formed  in 2007 as a spin-off from the University of Virginia to develop and commercialize low terahertz (THz) resonance spectroscopy for identification and characterization of biological materials and has received more than $2,000,000 in continuous funding from DOD SBIR & STTR Grants and Contracts. Vibratess develops technology and spectroscopic instrumentation for bio-materials characterization in the sub-THz frequency range. We also do molecular dynamic simulations to predict and analyze molecular absorption signatures produced by radiation in the sub-THZ frequency range.

Vibratess is a women owened Small Business, NAICS CODE: 541712, Research And Development In The Physical, Engineering & Life Sciences.

Sub-THz Technology Applications

Utilizing technology developed both at  UVA  and Vibratess, we built instruments for spectroscopic measurements in the sub-THz frequency range, tested these instruments, and conducted experimental characterization of diverse biological molecules and cells using our instruments. In parallel we developed and performed molecular dynamic (MD) simulations to predict absorption spectra of radiation by biological molecules in this frequency range, to create a database of spectroscopic signatures from  molecules of interest, to validate  the technology and  to facilitate the analysis of experimental results.

Relatively recently it became clear that THz waves could be important for life science applications because of the unique capability of this radiation to interact with low energy hydrogen bonds between atoms within biological molecules.   These weak bonds are vital for cellular processes and for biomolecules interactions relating to DNA, enzymes, proteins, ribosomes, and their functions.  Excitation of these vibrations produces specific molecular absorption spectral fingerprints and each type of biomolecules has its own vibrational signature, allowing each to be identified and characterized. Because sub-THz radiation propagates through an entire specimen, such as a bacterium, or biological cells, all molecular components can contribute to a detailed signature.  This optical technique can provide valuable information, in particular by monitoring molecular structural changes in response to physiological stimulus or by differentiation of different bacterial species that is possible with this method.

About Us


Past Performance

Continuous R&D funding over the last 9 years from SBIR & STTR Program contracts and grants issued by the Department of Defense, Office for Chemical and Biological Defense.

·      W911NF-13-C-0040 – THz Frequency Spectrometer Combined with Sub-Wavelength Microfluidic Platform (STTR Phase I)

·      W911NF-12-C-0112 & W911NF-12-C-0046 – Development of Biosensor Nanofluidic Platform for Integration with THz Spectroscopic System (SBIR Phase I & Phase II)

·      W911NF-11-C-0271 – THz Biosensor Based on Plasmonic Nanoarchitectures (STTR Phase I)

·      W911NF-10-C-0076 – Development of Biosensor Nanofluidic Platform for Integration with THZ Spectroscopic System (SBIR Phase I)

. W911NF-07-C-0055 & W911NF-08-C-0049 –Spectroscopic Imaging Technology for THz Biosensor Integrated with a Lab-on-Chip Platform (SBIR Phase I & Phase II).

Differentiators

Vibratess, LLC is the only company that develops and produces spectroscopic instrumentation for bio-materials characterization in the sub-THz frequency range.

·      Automated, simple optical spectroscopic & Microscopic instrument systems

·      Fast operating at room temperature with high sensitivity, high spectral resolution (selectivity), spatial resolution below diffraction limit ( ~150 mkm)

·      Integrated with a microfluidic chips for less than nano-gram sample materials

·      User friendly Operational Software for Spectroscopy Systems

·      Customized THz Biosensor Systems tailored for Specific Life Science Related Applications

. Customized THz chips for Dry and Nano-Fluidic Samples


 
Benefits of Sub-Terahertz Spectroscopy Sensing and Fingerprinting

Benefits of Sub-Terahertz Spectroscopy Sensing and Fingerprinting

Vibratess’ Services

·         THz Spectroscopic characterization of biological and organic materials: macromolecules and microorganisms.

·         Creating Experimental database for THz spectroscopic signatures from specific biological materials and objects.

·         Computational modeling for prediction and automated analysis of spectroscopic signatures from bio-materials.

·         Consulting services on potential applications of this new technology.

·         NAICS Code 541712 Research and Development in the Physical, Engineering & Life Sciences.

·         PSC Code B513 Special Studies/Analysis - Feasibility.

Measurements and Modeling Illustrations

Vibratess developed Sub-Terahertz resonance spectroscopy technology and innovative spectroscopic sensors to facilitate fast, optical, label-free and reagent-free, and improved molecular and cellular characterization analysis for life science applications, including but not limited to the early detection, diagnosis, prognosis and therapeutic treatment of cancers that are currently difficult, invasive and costly to detect.

Fig.5. Absorption spectrum of protein thioredoxin from  E. coli : MD simulation and experimental results from the Vibratess spectroscopic sensor

Fig.5. Absorption spectrum of protein thioredoxin from E. coli: MD simulation and experimental results from the Vibratess spectroscopic sensor

Fig.6. Absorption spectra of bacterial cells

Fig.6. Absorption spectra of bacterial cells

Fig. 7. Absorption spectra from Ovarian Cancer (OC-brown) & normal (green) samples.

Fig. 7. Absorption spectra from Ovarian Cancer (OC-brown) & normal (green) samples.

 

 
 
We must all obey the great law of change. It is the most powerful law of nature.
— Edmund Burke